个人简介
David Kaplan，1953年3月生，理学博士，教授，博士生导师。本科1975年毕业于美国Albany大学，1979毕业于美国Syracuse大学，现任美国Tufts 大学Stern Family Endowed 终身荣誉教授，生物医学系系主任兼化学工程系教授，美国国立卫生研究院（NIH）组织工程研究中心主任，在生物材料、组织工程研究领域，尤其是丝蛋白生物材料的研究领域有很深的造诣和极高的学术地位，承担多项美国国立卫生研究院、美国自然科学基金委的多项重大科研课题。在Nature杂志发表论文4篇，在Biomaterials、Biomicromolecular、Advanced Materials、Soft Materials、Tissue Engineering等高水平学术期刊发表论文400多篇，并同时担任Biomicromolecular副主编，Advanced Materials，Biomaterials，Tissue Engineering，Soft Materials等10多种高水平学术期刊编辑。已获得美国及世界专利20余项，并创办了三家以上高科技企业。David Kaplan教授积极与中国的科研人员展开合作，已于2011年受聘苏州大学现代丝绸国家工程实验室担任讲座教授，联合建立实验室，定期回国讲学并指导科研工作。
研究方向
天然可降解大分子材料在医疗、诊断、组织工程、光学等多个领域的应用。
荣誉及获奖情况
2010 波士顿New England Baptist 医院学术委员会成员
2009 北美组织工程协会常务理事
2007 美国生物材料协会 Clemson 奖金获得者
2003 美国医学和生物工程学会常务理事
2000 Biomacromolecules杂志副总编
近五年承担的科研项目
近五年发表的代表性论文论著专利等
1.Castro, C. R., J. Chen, B. Panilaitis, D. L. Kaplan (2009) Emulsan-alginate beads for protein adsorption. J. Biomaterials Science Polymer Education 20(4):411-426
2.Ghosh, S., M. Laha, S. Mondal, S. Sengupta, D. L. Kaplan (2009) In vitro model of mesenchymal condensation during chondrogenic development. Biomaterials 30(33): 6530-6540
3.Huang, J.; Cebe, P.; Kaplan, DL. (2009). Hierarchical assembly of collagen-like peptides in vitro – mimicking osteogenesisimperfecta. Macromolecular Rapid Communications. 30:336-344.
4.Kang, J. H., G. M. Gimble, D. L. Kaplan. (2009) In vitro 3D model for human vascularized adipose tissue. Tissue Engineering Part A. 15(8):2227-2236
5.Lawrence BD, MarchantJK, Pindrus MA, OmenettoFG, Kaplan DL. Silk film biomaterials for cornea tissue engineering. Biomaterials. 2009 Mar;30(7):1299-308.
6.Lawrence, B.; Omenetto, FG.; Kaplan, DL. (2009). Processing methods to control silk fibroin film biomaterial features. Journal of Materials Science, in press.
Lovett, M., K. Lee, A. Edwards, D. L. Kaplan (2009). Vascularization strategies for tissue engineering. Tissue Engineering Part B Reviews 15(3):353-370
7.Lu, S., X. Wang, Q. Lu, X. Hu, N. Uppal, F. G. Omenetto, D. L. Kaplan (2009) Stabilization of enzymes in silk films. Biomacromolecules 10(5):1032-1042 [
8.Motta, A., D. Maniglio, C. Migliaresi, H-J. Kim, X. Wang, X. Hu, D. L. Kaplan (2009). Silk fibroin processing and thrombogenic responses. J. Biomaterials Science Polymer Education. 20(13):1875-1897 Murphy, A., D. L. Kaplan. (2009). Biomedical applications of chemically modified silk fibroin. Journal of Materials Chemistry, 19(36):6443-6450
9.Numata, K., B. Subramanian, H. A. Currie, D. L. Kaplan (2009). Bioengineered silk protein-based gene delivery systems. Biomaterials. 30(29):5775-5784
10.Qin, G., S. Lapidot, K. Numata, X. Hu, S. Meirovitch, M. Dekel, I. Podoler, O. Shoseyov, D. L. Kaplan (2009) Expression,crosslinking and characterization of recombinant chitin binding resilin. Biomacromolecules 10(12):3227-3234
11.Rabotyagova, OS.;Cebe, P.; Kaplan, DL. (2009). Self-assembly of genetically engineered spider silk block copolymers. Biomacromolecules, 10(2):229-236
12.Seda, Tigli R, S. Ghosh, M. Laha, N. K. Shevde, L. Daheron, J. Gimble, M. Gumusderelioglu, D. L. Kaplan (2009) Comparative chondrogenesis of human cell sources on 3D scaffolds. J. Tissue Engineering and Regenerative Medicine 3(5):348-360
13.Sundelacruz, S., D. L. Kaplan (2009) Stem cell and scaffold based tissue engineering approaches to osteochondral regenerative medicine. Seminars Cell and Developmental Biology 20(6):646-655
14.Sundelacruz, S., M. Levin, D. L. Kaplan. (2009) Role of membrane potential in the regulation of cell proliferation and differentiation. Stem Cell Review. 5(3):231-246
15.Wang, X., X. Zhang, L. Sun, B. Subramanian, M. V. Maffini, A. Soto, C. Sonnenschein, D. L. Kaplan (2009) Preadipocytes stimulate ductal morphogenesis and functional differentiation of human mammary epithelial cells on 3D silk scaffolds. Tissue Engineering Part A 15(10):3087-3098
16.Wang, X., T. Yucel, Q. Lu, X. Hu, D. L. Kaplan. 2009. Silk nanospheres and microspheres from silk/PVA blend films for drug delivery. Biomaterials 31(6):1025-1035
17.Wang, X, E. Wenk, X. Zhang, L. Meinel, G. Vunjak-Novakovic, D. L. Kaplan (2009) Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering. J. Controlled Release 134(2):81-90
18.Yucel, T., N. Kojic, G. G. Leisk, T. J. Lo, D. L. Kaplan (2009) Non-equilibrium silk fibroin adhesives. Journal Structural Biology Dec 21 Epub ahead of print
19.Yucel, T., P. Cebe, D. L. Kaplan (2009) Vortex induced injectable silk fibroin hydrogels. Biophysical Journal 97(7):2044-2050
20.Zhang, X., M. R. Reagan, D. L. Kaplan (2009) Electrospun silk biomaterial scaffolds for regenerative medicine. Advance Drug Delivery Reviews 61(12):988-1006
21.Zhang, X., X. Wang, V. Keshav, X. Wang, J. T. Johanas, G. G. Leisk, D. L. Kaplan (2009) Dynamic culture conditions to generate silk-based tissue engineered vascular grafts. Biomaterials 30(19): 3213-3223
22.Chang, G., H. J. Kim, G. Vunjak-Novakovic, D. L. Kaplan, R. Kandel (2010) Enhancing annulus fibrosus tissue formation in porous silk scaffolds. J. Biomedical Materials Research 92(1):43-51
23.Chao, P. H., S. Yodmuang, X. Wang, L. Sun, D. L. Kaplan. G. Vunjak-Novakovic. Silk hydrogel for cartilage tissue engineering. J. Biomedical Materials Research B. Applied Biomaterials. 95(1): 84-90
24.Choi, J. H., J. M. Gimble, K. Lee, K. G. Marra, J. P. Rubin, J. J. Yoo, G. Vunjak-Novakovic, D. L. Kaplan. 2010. Adipose tissue engineering for soft tissue regeneration. Tissue Engineering Part B. Reviews 16(4): 413-426
25.Domachuk, P., K. Tsioris, F. G. Omenetto, D. L. Kaplan. 2010. Bio-microfluidics: biomaterials and biomimetic designs. Advanced Materials 22(2):249-260 [PMID: 20217636]
26.Gil, E. S.; S. H. Park, J. Marchant, F. Omenetto, D. L. Kaplan. 2010. Response of human corneal fibroblasts on silk film surface patterns. Macromolecular Bioscience. 10(6): 664-673
27.Gil, E. S., S. H. Park, S. Hudson, D. L. Kaplan. 2010. Mechanically robust rapidly actuating and biologically functionalized macroporouspoly(N-isopropylacrylamide)silk hybrid hydrogels. Langmuir. 26(19): 15614-15624
28.Gil, E. S., B. B. Mandal, S. H. Park, J. K. Marchant, F. G. Omenetto, D. L. Kaplan. 2010. Helicoidal multi-lamellar features of RGD-functionalized silk biomaterials for corneal tissue engineering. Biomaterials 31(34): 8953-8963.
29.Hechavarria, D., A. Dewilde, S. Braunhut, M. Levin, D. L. Kaplan. 2010. Biodome regenerative sleeve for biochemical and biophysical stimulation of tissue regeneration. Medical Engineering and Physics 32(9):1065-1073
30.House, M., C. C. Sanchez, W. L. Rice, S. Socrate, D. L. Kaplan. 2010. Cervical tissue engineering using silk scaffolds and human cervical cells. Tissue Engineering Part A 16(6):2101-2112
31.Hu, X., X. Wang, J. Rnjak, A. S. Weiss, D. L. Kaplan. 2010. Biomaterials derived from silk-tropoelastin protein systems. Biomaterials, 31(32): 8121-8131
32.Hu, X., Q. Lu, L. Sun, P. Cebe, X. Wang, X. Zhang, D. L. Kaplan. 2010. Biomaterials from ultrasonic-induced silk fibroinhyaluronic acid hydrogels. Biomacromolecules. Oct 13, ahead of print
33.Kwon, H., H. J. Kim, W. R. Rice, B. Subramanian, S. H. Park, I. Georgakoudi, D. L. Kaplan. 2010. Development of an in vitro model to study the impact of BMP-2 on metastasis to bone. J. Tissue Engineering and Regenerative Medicine 4(8): 590-599
34.Lawrence, B., D., S. Wharram, J. A. Kluge, G. G. Leisk, F. G. Omenetto, M. I. Rosenblatt, D. L. Kaplan. 2010. Effect of hydration on silk film materials properties. Macromolecular Bioscience 10(4):393-403
35.Leisk, G.G., T. Lo, T. Yucel, Q. Lu, D. L. Kaplan. 2010. Electrogelation for protein adhesives. Advanced Materials 22(6):711-7115
36.Lovett, M., D. N. Rockwood, A. Baryshyan, D. L. Kaplan. 2010. Simple modular bioreactors for tissue engineering: a system for characterization of oxygen gradients, hMSC differentiation, and prevascularization. Tissue Engineering Part C Methods 16(6): 1565-1573
37.Lovett, M., G. Eng, J. Kluge, C. Cannizzaro, G. Vunjak-Novakovic, D. L. Kaplan. 2001. Tubular silk scaffolds for small diameter vascular grafts. Organogenesis 6(4):217-224
38.Lu, Q., X. Wang, X. Hu, P. Cebe, F. Omenetto, D. L. Kaplan. 2010. Stabilization and release of enzymes from silk films Macromolecular Bioscience 10(4):359-368
39.Lu, Q., X. Zhang, X. Hu, D. L. Kaplan. 2010. Green process to prepare silk fibroin/gelatin biomaterial scaffolds. Macromolecular Bioscience 10(3):289-298
40.Lu, S., X. Wang, Q. Lu, X. Zhang, J. A. Kluge, N. Uppal, F. Omenetto, D. L. Kaplan. 2010. Insoluble and flexible silk films containing glycerol. Biomacromolecules 11(1): 143-150
41.Lu, Q., X. Hu, X. Wang, J. A. Kluge, S. Lu, P. Cebe, D. L. Kaplan. 2010. Water insoluble silk films with silk 1 structure. ActaBiomaterialia 6(4): 1380-1387
42.Mieszawaka, A. J., D. L. Kaplan. 2010. Smart biomaterials – regulating cell behavior through signaling molecules. BMC Biology 19(8):59
43.Mieszawaka, A.J., L. D. Nadkarni, C. C. Perry, D. L. Kaplan. 2010. Nanoscale control of silica particle formation via silksilica fusion proteins for bone regeneration. Chemistry of Materials, 22(20): 5780-5785
44.Mieszawska, A. J. N. Fourligas, I. Georgakoudi, N. M. Ouhib, D. J. Bleton, C. C. Perry, D. L. Kaplan. 2010. Osteoinductive silk-silica composite biomaterials for bone regeneration. Biomaterials 31(34): 8902-8910
45.Numata, K., J. Hamasaki, B. Subramanian, D. L. Kaplan. 2010. Gene delivery mediated by recombinant silk proteins containing cationic and cell binding motifs. Journal Controlled Release 146(1):136-143
46.Numata, K., P. Cebe, D. L. Kaplan. 2010. Mechanisms of enzymatic degradation of beta sheet crystals. Biomaterials 31(10):2926-2933
47.Numata, K., D. L. Kaplan. 2010. Mechanisms of enzymatic degradation of amyloid beta microfibrils generating nanofilaments and nanospheres related to cytotoxicity. Biochemistry. 49(15): 3251-3260
48.Numata, K., D. L. Kaplan. 2010. Silk based delivery systems of bioactive molecules. Advanced Drug Delivery Reviews 62(15): 1497-1508
49.Omenetto, F. G., D. L. Kaplan. 2010. SnapShot: silk biomaterials. Biomaterials 23:6119-6120
50.Omenetto, F. G., D. L. Kaplan. 2010. New opportunities for an ancient material. Science. 329(5991):528-531
51.Park, S. H., E. S. Gil, H. J. Kim, K. Lee, D. L. Kaplan. 2010. Relationships between degradability of silk scaffolds and osteogenesis. Biomaterials 24:6162-6272
52.Pritchard, E. M. C. Szybala, D. Boison, D. L. Kaplan. 2010. Silk fibroin encapsulated powder reservoirs for sustained release of adenosine. J. Controlled Release 144(2):159-167
53.Rabotyagova, OS.;Cebe, P.; Kaplan, DL. (2010). Role of polyalanine domains in beta sheet formation in spider silk block copolymers. Macromolecular Bioscience 10(1):49-59
54.Rajkhowa, R., E. S. Gil, J. Kluge, K. Numata, L. Wang, X. Wang, D. L. Kaplan. 2010. Reinforcing silk scaffolds with silk particles. Macromolecular Bioscience. 10(6): 599-611
55.Reagan, M. R., L. Faverman, R. Goldstein, M. Rosenblatt, D. L. Kaplan. 2010. Disease modeling and tissue engineering: breast cancer metastasis to bone. Cancer Treatment Reviews 34:16.
56.Sengupta, S., S. Park, A. Patel, J. Carn, K. Lee, D. L. Kaplan. 2010. Hypoxia and amino acid supplementation synergistically promote the osteogenesis of human mesenchymal stem cells on silk protein scaffolds. Tissue Engineering Part A. 16(12): 3623-3634
57.Sengupta, S., S. Park, K. Lee, D. L. Kaplan. 2010. Quantifying osteogenic cell degradation of silk biomaterials. Biomacromolecules. 11(12):3592-3599
58.Serban, M., D. L. Kaplan. 2010. pH sensitive ionomeric particles via chemical conjugation of silk with poly-amino acids. Biomacromolecules. 11(12): 3406-3412
59.Serban, M., D. L. Kaplan. 2010. Modular elastic biomaterial patches – mechanical and biological functions. Biomacromolecules. 11(9): 2230-2237
60.Subramanian, B., D. Rudym, C. Cannizzaro, R. Peronne, J. Zhou, D. L. Kaplan. 2010. Tissue engineered 3D in vitro models for normal and diseased kidney. Tissue Engineering Part A, 16(9): 2821-2831
61.Vepari, C., D. Matheson, L. Drummy, R. Naik, D. L. Kaplan. 2010. Surface modification of silk fibroin with poly(ethylene glycol) for anti-adhesion and antithrombotic applications. J. Biomedical Materials Research. 93(2): 595-606
62.Wang, X., T. Yucel, Q. Lu, D. L. Kaplan. 2010. Silk nanospheres and microspheres from silk PVA blend films for drug delivery. Biomaterials 31(6):1025-1035
63.Wang, X., L. Sun, M. V. Maffini, A. Soto, C. Sonnenschein, D. L. Kaplan. 2010. A complex 3D human tissue culture system based on mammary stromal cells and silk scaffolds for modeling breast morphogenesis and function. Biomaterials. 31(14):3920-3929
64.Wang, X, M. R. Reagan, D. L. Kaplan. 2010. Synthetic adipose tissue models for studying mammary gland development and breast tissue engineering. Journal of Mammary Gland Biology and Neoplasia. 15(3): 365-376
65.Yadov, V., B. J. Paniliatis, H. Shi, K. Lee, P. Cebe, D. L. Kaplan. 2010. A novel in vivo degradable cellulose-chitin copolymer from metabolically engineered Gluconacetobacterxylinus. Applied Environmental Microbiology. 76(18): 6257-6265
66.Yucel, T., N. Kojic, G. G. Leisk, T. J. Lo, D. L. Kaplan. 2010. Non-equilibrium silk fibroin adhesives. Journal Structural Biology 170(2):406-412
67.Choi, J. H., E. Bella, G. Vunjak-Novakovic, D. L. Kaplan. 2011. Adiopogenic differentiation of human adipose-derived stem cells on 3D silk scaffolds. Methods Molecular Biology. 702: 319-330 Choi, J. H., E. Bellas, J. M. Gimble, G. Vunjak-Novakovic, D. L. Kaplan. 2011. Lipolytic function of adipocyte/endothelial cell cocultures. Tissue Engineering Part A, 17(9-10): 1437-1444.
68.Choi, J. H., J. M. Gimble, G. Vunjak-Novakovic, D. L. Kaplan, 2011, Effects of hyperinsulinemia on lipolytic function of three dimensional adipocyte/endothelial co-cultures. Tissue Engineering Part C. Methods. 702:319-330
69.Gil, E. S., J. A. Kluge, D. N. Rockwood, R. Rajkhowa, L. Wang, X. Wang, D. L. Kaplan. 2011. Mechanical improvements to reinforced porous silk scaffolds. J. Biomaterial Materials Research A. 99(1): 16-28.
70.Gomes, S.C, I B. Lenore, J. F. Mano, R. L. Resis, D. L. Kaplan. 2011. Antimicrobial functionalized genetically engineered spider silk. Biomaterials. 32(18): 4255-4266.
71.Gomes, S. C., K. Numata, I. B. Lenor, J. F. Mano, R. L. Reis, D. L. Kaplan. 2011. AFM study of morphology and mechanical properties of a chimeric spider silk and bone sialoprotein for bone regeneration. Biomacromolecules 12(5): 1675-1685.
72.Gomes, S. C., K. Numata, I. B. Lenor, J. F. Mano, R. L. Reis, D. L. Kaplan. 2011. Spider silk-bone sialoprotein fusion proteins for bone tissue engineering. Soft Matter. In press.
73.Guziewicz, N., A. Best, B. Perez-Ramierez, D. L. Kaplan. 2011. Lyophilized silk fibroin hydrogels for the sustained local delivery of therapeutic monoclonal antibodies. Biomaterials, 32(10): 2642-2650.
74.Hines, D. J., D. L. Kaplan. 2011. Mechanisms of controlled release from silk fibroin films. Biomacromolecules. 12(3): 804-812
75.House, M., J. Daniel, K. Elstad, S. Socrate, D. L. Kaplan. 2011. Oxygen tension and formation of cervical like tissue in two dimensional and three dimensional culture. Tissue Eng. Part A. Nov 1, ahead of print.
76.Hronik-Tupaj, M., D. L. Kaplan. 2011. A review of the responses of 2D and 3D engineered tissues to electric fields. Tissue Engineering Part B. Reviews. Nov 3, ahead of print
77.Hu, X., K. Shmelev, L. Sun, E.S. Gil, S. H. Park, P. Cebe, D. L. Kaplan. 2011. Regulation of silk material structure by temperature controlled water vapor annealing. Biomacromolecules. 12 (5):1686-1696
78.Hu, X., S. H. Park, E. S. Gil, X. Xia, A. S. Weiss, D. L. Kaplan. 2011. The influence of elasticity and surface roughness on myogenic and osteogenic differentiation of cells on silk elastin biomaterials. Biomaterials. 32(34): 8979-8989.
79.Karve, K. A., E. S. Gil, S. P. McCarthy, D. L. Kaplan. 2011. Effect of beta sheet crystalline content on mass transfer in silk films. J. Membrane Science 383(1-2):44-49.
80.Kluge, J., G. Leisk, R. Cardwell, A. Fernandes, A. Ward, L. Dorfmann, D. L. Kaplan. 2011. Bioreactor system for biomaterial design studies utilizing real time mechanical loading control and noninvasive imaging. Annals of Biomedical Engineering. 39(5): 1390-1402
81.Krishnaji, S. T., W. Huang, O. Rabotyagova, E. Kharlampieva, I. Choi, V. V. Tsukruk, R. Naik, P. Cebe, D. L. Kaplan. 2011. Thin film assembly of spider silk like block copolymers. Langmuir 27(3): 1000-1008
82.Lovett, M.; G. Eng, J. A. Kluge, C. Cannizzaro, G. Vunjak-Novakovic, D. L. Kaplan. 2011. Tubular silk scaffolds for small diameter vascular grafts. Organogenesis 6(40): 217-224.
83.Lu, Q, X. Wang, H. Zhu, D. L. Kaplan. 2011. Surface immobilization of antibody on silk fibroin through conformational transition. ActaBiomaterialia. 7(7): 2782-2786.
84.Lu, Q., Y. Huang, M. Li, B. Zuo, S. Lu, J. Wang, H. Zhu, D. L. Kaplan. 2011. Silk fibroin electrogelation mechanisms. ActaBiomaterialia. 7(6): 2394-2400.
85.Mandal, B. B., S. H. Park, E. S. Gil, D. L. Kaplan. 2011. Multilayered silk scaffolds for meniscus tissue engineering. Biomaterials 32(2) 639-651
86.Mandal, B. B., S. H. Park, E. S. Gil, D. L. Kaplan, 2011. Stem cell based meniscus tissue engineering. Tissue Engineering Part A. 17(21-22): 2749-2761.
87.Mauney, J. R., G. M. Cannon, M. L. Lovett, E. M. Gong, D. Di Vizio, P. Gomez 3rd, D. L. Kaplan, R. M. Adam, C. R. Estrada Jr. 2011. Evaluation of gel spun silk-based biomaterials in a murine model of bladder augmentation. Biomaterials 32(3): 808-818
88.Mieszawska, J. J., J. G. Llamas, C. A. Vaiana, M. P. Kadakia, R. R. Naik, D. L. Kaplan. 2011. Clay enriched silk biomaterials for bone formation. ActaBiomaterialia. 7(8): 3036-3041.
89.Nectow, A. R., K. G. Marra, D. L. Kaplan. 2011. Biomaterials and the development of peripheral nerve guidance conduits. Tissue Engineering Part B, Reviews. Sep 23 ahead of print.
90.Numata, K., D. L. Kaplan. 2011. Differences in cytotoxicity of beta-sheet peptides originated from silk and amyloid beta. Macromolecular Bioscience 11(1): 60-64
91.Numata, K., D. L. Kaplan. 2011. Silk-based gene carriers with cell membrane-destabilizing peptides. Biomacromolecules. Oct 13, ahead of print
92.Numata, K., A. J. Mieszawska-Czajkowska, L. A. Kvenvold, D. L. Kaplan. 2011. Silk-based nanocomplexes with tumor homing peptides for tumor specific gene delivery. Macromolecular Bioscience. Nov. 3, ahead of print.
93.Numata, K., M. R. Reagan, R. H. Goldstein, M. Rosenblatt, D. L. Kaplan. 2011. Spider silk based gene carriers for tumor cell specific delivery. Bioconjugate Chemistry. 22(8): 605-1610.
94.Oliverira, A. L. L. Sun, H. J. Kim, X. Hu, W. Rice, J. Kluge, R. L. Reis, D. L. Kaplan. 2011. Aligned silk based 3D architectures for contact guidance in tissue engineering. ActaBiomaterialia Dec 16, ahead of print.
95.Park, S. H., A. Tofighi, X. Wang, M. Strunk, T. Richketts, J. Chang, D. L. Kaplan. 2011. Calcium phosphate combination biomaterials as human mesenchymal stem cell delivery vehicles for bone repair. J. Biomedical Materials Research B. Applied Biomaterials. 97(2): 235-244.
95.Park, S. H., E. S. Gil, H. Cho, B. B. Mandal, L. W. Tien, B. H. Min, D. L. Kaplan. 2011. Intervertebral disk tissue engineering using biphasic silk composite scaffolds. Tissue Engineering Part A, Oct 26, ahead of print.
97.Park, S. H., H. Cho, E. S. Gil, B. B. Mandal, B. H. Min, D. L. Kaplan. 2011. Silk fiboin hyaluronic acid composite gels for nucleus pulposus tissue regeneration. Tissue Engineering Part A, Aug 23, ahead of print.
98.Pritchard, E. M., T. Valentin, D. Boison, D. L. Kaplan. 2011. Incorporation of proteinase inhibitors into silk-based delivery devices for enhanced control of degradation and drug release. Biomaterials 32(3): 909-918
99.Pritchard, E. M., D. L. Kaplan. 2011. Silk fibroin biomaterials for controlled release drug delivery. Expert Opinion Drug Delivery, 8(6): 797-811.
100.Qin, G., D. L. Kaplan. 2011. Silk biomaterials, in An Introduction to Biomaterials, Second Edition. In press.
101.Qin, G., A. Rivkin, S. Lapidot, X. Hu, I. Presis, S. B. Arinus, O. Dgany, O. Shoseyov, D. L. Kaplan. 2011. Recombinant exon encoded resilins for elastomeric biomaterials. Biomaterials 32(35): 9231-9243.
102.Rabotyagova, O. S., P. Cebe, D. L. Kaplan. 2011. Protein-based block copolymers. Biomacromolecules. 12(2): 269-289
103.Reagan, M. R., D. L. Kaplan. 2011. Concise Review: mesenchymal stem cell tumor-homing: detection methods in disease model systems. Stem Cells. 29(6): 920-927.
104.Rockwood, D. N., E. S. Gil, S. H. Park, J. A. Kluge, W. Grayson, S. Bhumiratana, R. Rajkhowa, X. Wang, S. J. Kim. G. Vunjak-Novakovic, D. L. Kaplan. 2011. Ingrowth of human mesenchymal stem cells into porous silk particle reinforced silk composite scaffolds: an in vitro study. ActaBiomaterialia, 7(1): 144-151
105.Rockwood, C. Preda, T. Yucel, X. Wang, M. Lovett, D. L. Kaplan. 2011. Materials fabrication from Bombyxmori silk fibroin. Nature Protocols 6(10): 1612-1631.
106.Serban, M. A., B. Panilaitis, D. L. Kaplan. 2011. Silk fibroin and polyethylene glycol based biocompatible tissue adhesives. J. Biomaterials Materials Research A. 98(4): 567-575.
107.Sun, L., M. R. Reagan, D. L. Kaplan. 2011. Role of cartilage forming cells in regenerative medicine in cartilage repair. Orthopedic Research and Reviews 2:1-10. In press.
108.Sun, L., X. Wang, D. L. Kaplan. 2011. A 3D cartilage inflammatory cell culture system for the modeling of human osteoarthritis. Biomaterials 32(24): 5581-5589.
109.Tigli, R. S., C. Cannizaro, M. Gumusderelioglu, D. L. Kaplan. 2011. Chondrogenesis in perfusion bioreactors using porous silk scaffolds and hESC-derived MSCs. J. Biomedical Materials Research A 96(1): 21-28
110.Wang, X., D. L. Kaplan. 2011. Functionalization of silk fibroin with NeutrAvidin and biotin. Macromolecular Bioscience 11(1): 100-110
111.Wray, L. S., X. Hu, J. Gallego, I. Georgakoudi, F. G. Omenetto, D. Schmidt, D. L. Kaplan. 2011. Effect of processing on silk-based biomaterials: reproducibility and biocompatibility. J. Biomedical Materials Research, Part B: Applied Biomaterials. 99(1): 89-101.
112.Xia, X., Q. Xu, X. Hu, G. Qin, D. L. Kaplan. 2011. Tunable self-assembly of genetically engineered silk-elastin-like protein polymers. Biomacromolecules. 12(11): 3844-3850.
联系方式
Divid.kaplan@tufts.edu; wangxiaoqin@suda.edu.cn